Four classes of viral vector have been developed for use in human gene therapy and have reached phase 1 clinical trials. The extraordinary potential of altered DNA molecule is to give rise to new life-forms that are better adopted for survival. Supporters of the use of transgenic animals point out their importance for people who need insulin treatment and those who are undergoing treatment with the use of gene therapy.
Successful gene transfer to such cells usually requires a good deal of research before selecting any particular gene delivery method. As people learn about the positive and negative use of transgenic animals, they will learn things that can help them in deciding whether the idea of using animals is favorable or not.
Transgenic animals are essentially being produced so that they benefit humanity in some way. Because of the possibility of genetically modifying DNA, scientists will be able to allow such animals to produce blood clotting factors, insulin, and vaccines, among others. The first reason is that some of them are produced for certain economic traits.
The second route is termed transfection, and this encompasses a number of techniques, some chemical and some physical, which can be used to persuade cells to take up DNA from their surroundings. Subject for Clinical Trials.
But what is a journal without readers? In the second case, known as stable gene delivery, expression of the transferred gene is prolonged, or stable, because the vector is integrated into the host cell chromosome.
Conversely, rod-shaped viruses such as the baculoviruses form the capsid around the genome, so there are no such size constraints.
With the use of transgenic animals, people are able to make use of gene therapy and insulin produced by these animals to cure or help in treating particular diseases. Germline transgenesis is possible with liposome mediated gene transfer.
The Cons of Transgenic Animals 1. At the entry site, endonucleases cut the DNA into fragments of 7, nucleotides, and the double-stranded DNA separates into single strands.
The following are cons that you should take note of: Despite the practice to be in existence for years now, transgenic animals still remains to be a divisive issue. The following are cons that you should take note of: For example, icosahedral viruses such as adenoviruses and retroviruses package their genomes into preformed capsids, whose volume defines the maximum amount of foreign DNA that can be accommodated.
The transfer of foreign DNA into a cell by this route is termed transduction. But with various ways developed in testing particular discoveries, experts should consider using new ways of testing instead of risking the lives of animals.
The only problem is that the issues our society faces with transgenic animals might outweigh those advantages. With the use of this biotechnology, cattle and sheep can already be used in transgenesis.
This leads to a fusion between cationic liposome and the cell surface resulting in quick entry by endocytosis and the delivery of the DNA directly across the plasma membrane.
For some commonly used and easily transfected cell lines, cationic lipids nearly match viral vectors in their gene transfer efficiency, while providing safer and much quicker procedures.
With their help, pharmaceuticals are able to come up with the cure for certain diseases. The Pros of Transgenic Animals 1. Transgenic animals can be engineered to do a number of different things for economic purposes.
Unsafe for Human Intake. The major advantages of the technique are its relative simplicity and speed, limited expense, and remarkably reproducible interexperimental and intraexperimental transfection efficiency.
What Is a Transgenic Animal? Viral gene delivery is perhaps the second most expensive method, since it requires the vector reagents, extensive time and labor to complete lengthy vector preparation procedures, as well as proper disposal of viral waste materials.
It can be used to delete a gene, add a gene and introduce point mutations. Grows easily than of real animals. Final Thoughts The use of transgenic animals for human treatment and well-being has become a debatable issue.
Welcome Message Index Copernicus Value: Cationic liposomes can be produced from a number of cationic lipids that are commercially available and sold as an in vitro-transfecting agent, termed lipofectin. The negatively charged DNA binds to the polycation and the complex is taken up by the cell via endocytosis.
The decision whether to trust the advocates or believe in the negative impact as claimed by critics will remain by weighing the pros and cons first to avoid regrets. Transgenes may be incorporated into viral vectors either by addition to the whole genome or by replacing one or more viral genes.
For example, targeting nucleic acids to particular cells while avoiding other cells is usually a major concern for in vivo gene transfer applications, sometimes a concern for ex vivo applications, but usually not a concern for in vitro applications.PROS: Common Counter-Arguments: Development of pest-tolerant plants can increase productivity while reducing pesticide use.
 [Not enough is known about whether pesticides built into plants are safe for human consumption. Home Issues Transgenic Animals Pros and Cons. Issues; Transgenic Animals Pros and Cons. May 11, 0. Transgenesis was initially performed with a mouse and the process was a large success.
Since that time, transgenesis was performed on other types of animals like cattle, pigs, sheep and rabbits. Pros and Cons of Economic Growth Fostering economic growth remains at the heart of any national government’s agenda.
As such, governments have embraced numerous strategies aimed at promoting economic growth, such as forging alliances, signing business treaties, and becoming members to business alliances.
Pros and Cons of Transgenic Animals Even though scientists are able to create transgenic animals, whether or not scientists should create transgenic animals is a question to ponder. There are both pros and cons when it comes to transgenic animals. Transgenic Animals Pros and Cons. May 11, 0. Share on Facebook.
Transgenesis was initially performed with a mouse and the process was a large success. Since that time, transgenesis was performed on other types of animals like cattle, pigs, sheep and rabbits. There are reasons why transgenic animals are being produced.
Free Essay: Zoë Zegers 05/06/10 Richetelli 3/4 Transgenic Organisms Transgenic organism is an organism that has been engineered to carry genes from another.Download